Liquivent® Lung Lavage Solution
A clear perfluorocarbon (PFC) solution for lung lavage. Intended to aid in the removal of foreign material and tenacious bronchial secretions.
The water-clear, very dense, low-viscosity PFC liquid is immiscible with both water and lipids. Due to its high density it easily penetrates to the lowest levels in the lung to displace most solids* and liquids, causing those to float to the top of the meniscus where they are easily suctioned out.
Clinical studies have shown that PFC’s are eliminated from the lungs primarily by evaporation, with radiographic clearance of most of the PFC’s by 48 hours1. In addition, PFC use in the lungs enhances surfactant phospholipid production4. Instillation of Perflubron into the lungs was found to actually diminish oxidation damage to injury prone tissues5, and when used with exogenous surfactant, PFC actually improved pulmonary gas exchange after meconium aspiration6.
*Solids such as food, smoke, charcoal, mucus & dust.
1) Reickert C, Pranikoff T, Overbeck M, Kazerooni E, Massey K, Bartlett R, Hirschl R. “The Pulmonary And Systemic Distribution And Elimination Of Perflubron From Adult Patients Treated With Partial Liquid Ventilation” Chest. 2001 Feb; 119(2):515-522
2) PFC Molecular weights > 480
3) Vapor pressure > 5.9 mbar @ 20 C
4) Steinhorn DM, Leach CL, Fuhrman BP, Holm BA. “Partial Liquid Ventilation Enhances Surfactant Phospholipid Production.” Critical Care Med. 1996 Jul; 24(7):1252-6.
5) Rotta AT, Gunnarsson B, Fuhrman BP, Wiryawan B, Hernan LJ, Steinhorn DM. “Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems.”Pediatr Crit Care Med. 2003 Apr;4(2):233-8.
6) Schlösser R, L, Veldman A, Fischer D, Funk B, Brand J, von Loewenich V. “Comparison of Effects of Perflubron and Surfactant Lung Lavage on Pulmonary Gas Exchange in a Piglet Model of Meconium Aspiration.” Biol Neonate. 2002 Feb; 81:126–131